A mile-wide area was evacuated after a freight train derailed in Columbus, Ohio, early Wednesday, causing an explosion and fire.

Two people who were close by when the train derailed were injured. The victims drove themselves to the hospital but their conditions are unknown.

The train crew was able to safely move the locomotives and three freight cars from the scene. There were no injuries to train personnel.

Teams trained to deal with hazardous materials are on the scene of the blaze, near the Ohio State Fairgrounds in north Columbus.

According to Mike McNutt with Columbus Public Health, several of the train cars contained styrene which, if ignited, can emanate a gas that affects the nervous system if inhaled.